SML0752

(+)-CP-99994 dihydrochloride

≥98% (HPLC), neurokinin (NK)-1 tachykinin antagonist, powder

• Synonym(s): (2S,3S)-3-(2-Methoxybenzylamino)-2-phenylpiperidine dihydrochloride, CP-99,994, CP-99994, CP99,994, CP99994
• Empirical Formula (Hill Notation): C₁₉H₂₄N₂O · 2HCl
• CAS Number: 145148-39-6
• Molecular Weight: 369.33
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: (+)-CP-99994 dihydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 15 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [Cl-].[Cl-].[N+H2]1[C@H]([C@H](CCC1)[N+H2]Cc3c(cccc3)OC)c2ccccc2
• InChI: 1S/C19H24N2O.2ClH/c1-22-18-12-6-5-10-16(18)14-21-17-11-7-13-20-19(17)15-8-3-2-4-9-15;;/h2-6,8-10,12,17,19-21H,7,11,13-14H2,1H3;2*1H/t17-,19-;;/m0../s1
• InChI key: WNHRFWPLRATIDT-FFUVTKDNSA-N

Description

Biochem/physiol Actions

(+)-CP-99994 is a selective neurokinin (NK)-1 tachykinin antagonist.

(+)-CP-99994 is a selective neurokinin (NK)-1 tachykinin antagonist. (+)-CP-99994 binds selectively and with high affinity with a Ki of 0.25 nM in a human cell line.

(+)-CP-99994 dihydrochloride is an effective and selective non-peptide substance P receptor antagonist. It is synthesized from allylic and homoallylic C-H diamination of 4-phenyl-1-butene. (+)-CP-99994 exhibits anti-emetic activity in ferrets.

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable