SAB3500666

Anti-TRMT12 antibody produced in rabbit

affinity isolated antibody

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Mol-Gew.: 49 kDa
• Speziesreaktivität: human, mouse
• Konzentration: 1 mg/mL
• Methode(n): ELISA: suitable; immunocytochemistry: suitable; western blot: suitable
• UniProt-Hinterlegungsnummer: Q53H54
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TRMT12(55039)

Beschreibung

Allgemeine Beschreibung

TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase.

Immunogen

Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2.

Biochem./physiol. Wirkung

TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints.

Leistungsmerkmale und Vorteile

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Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500666.

Physikalische Form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable