S8688

SR 59230A

≥98% (HPLC), powder, β3-Adrenoceptor antagonist

• Synonym(e): 3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt
• Empirische Formel (Hill-System): C₂₁H₂₇NO₂ · C₂H₂O₄
• CAS-Nummer: 174689-39-5
• Molekulargewicht: 415.48
• MDL-Nummer: MFCD00940163
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278715
• NACRES: NA.77

Eigenschaften

• product name: SR 59230A, ≥98% (HPLC), powder
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: DMSO: >10 mg/mL; H₂O: insoluble
• Ersteller: Sanofi Aventis
• SMILES String: OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23
• InChI: 1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
• InChIKey: XTBQNQMNFXNGLR-MKSBGGEFSA-N
• Angaben zum Gen: human ... ADRB3(155)

Beschreibung

Anwendung

SR 59230A was used in the identification of β-adrenoceptors in rat aorta.³ It was tested as a potential therapeutic agent in improving cardiac function in rat model of heart failure.⁴

Biochem./physiol. Wirkung

SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.¹ It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.²

Leistungsmerkmale und Vorteile

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)