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S0693

Sigma-Aldrich

SB 204741

>98% (HPLC)

Synonym(e):

N-(1-Methyl-1H-5-indolyl)-N′-(3-methyl-5-isothiazolyl)urea

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About This Item

Empirische Formel (Hill-System):
C14H14N4OS
CAS-Nummer:
152239-46-8
Molekulargewicht:
286.35
MDL-Nummer:
MFCD00923644
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278321
NACRES:
NA.77

Qualitätsniveau

100

Assay

>98% (HPLC)

Form

solid

Farbe

off-white to tan

Löslichkeit

DMSO: soluble >20 mg/mL

Ersteller

GlaxoSmithKline

Lagertemp.

2-8°C

SMILES String

Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1

InChI

1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)

InChIKey

USFUFHFQWXDVMH-UHFFFAOYSA-N

Angaben zum Gen

human ... DRD2(1813) , DRD3(1814) , DRD5(1816) , HTR1E(3354) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
rat ... Adra1a(29412) , Gabra2(29706) , Htr1a(24473) , Htr2b(29581) , Htr3a(79246)

Anwendung

SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:
  • to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish
  • to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral studies in mice
  • to test its effect in reducing scratching behavior evoked by sertraline in mice

Biochem./physiol. Wirkung

SB 204741 reduces the synaptic facilitation induced by the low dose of buprenorphine in spinal C-fiber synapses.
5-HT2B serotonin receptor antagonist.

Leistungsmerkmale und Vorteile

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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