R101

Ranitidin -hydrochlorid

H2 histamine receptor antagonist;, solid

• Empirische Formel (Hill-System): C₁₃H₂₂N₄O₃S · HCl
• CAS-Nummer: 66357-59-3
• Molekulargewicht: 350.86
• NACRES: NA.77
• PubChem Substance ID: 24277803
• UNSPSC Code: 12352200
• EC Number: 266-333-0
• MDL number: MFCD00069339
• Form: solid

Eigenschaften

• Produktname: Ranitidin -hydrochlorid, solid
• form: solid
• Quality Segment: 200
• color: tan
• solubility: H₂O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
• originator: GlaxoSmithKline
• SMILES string: Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
• InChI: 1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
• InChI key: GGWBHVILAJZWKJ-CHHCPSLASA-N
• Gene Information: human ... HRH2(3274)

Beschreibung

Application

Ranitidine hydrochloride has been used as a reference compound for the development and validation of parallel artificial membrane permeability assay (PAMPA).

Biochem/physiol Actions

H₂ Histamin-Rezeptorantagonist; Antiulcusmittel

Ranitidine is mainly used to treat gastrointestinal impairment instigated by non-steroidal anti-inflammatory drugs (NSAIDs).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H317,H319,H334,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)