P0108

PRL-3 Inhibitor I

≥98% (HPLC), solid

• Synonym(e): 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone, Phosphatase of regenerating liver-3, Inhibitor I
• Empirische Formel (Hill-System): C₁₇H₁₁Br₂NO₂S₂
• CAS-Nummer: 893449-38-2
• Molekulargewicht: 485.21
• MDL-Nummer: MFCD11045303
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329820016
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: protect from light
• Farbe: yellow
• Löslichkeit: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• Lagertemp.: −20°C
• SMILES String: Brc1ccc(OCc2ccccc2Br)c(c1)\C=C3\SC(=S)NC3=O
• InChI: 1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+
• InChIKey: HXNBAOLVPAWYLT-OVCLIPMQSA-N

Beschreibung

Anwendung

PRL-3 Inhibitor I has been used as an inhibitor of phosphatase of regenerating liver-3 (PRL-3):

• to test its effect on classical Hodgkin lymphoma cell survival
• in the human umbilical vein endothelial cells tube formation assay
• to test its effect on the migration of neural crest cells

Biochem./physiol. Wirkung

PRL-3 Inhibitor I is a rhodanine derivative with an IC₅₀ value of 0.9 μM against phosphatase of regenerating liver-3 (PRL-3), a nonclassical protein tyrosine phosphatase that has recently been shown to be involved in cancer metastasis. PRL-3 Inhibitor I reduced the invasiveness of B16F10 melanoma cells in a cell based assay.

Leistungsmerkmale und Vorteile

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves