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GW22821

Sigma-Aldrich

Anti-TCOF1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

chicken

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Hersteller/Markenname

Genway 15-288-22821

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NP_000347.1

UniProt-Hinterlegungsnummer

Q13428

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... TCOF1(6949)

Verwandte Kategorien

Immunogen

Immunogen Sequence: GI # 4507411, sequence 4-193
Recombinant treacle

Anwendung

Anti-TCOF1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Treacle protein is a protein encoded by the TCOF1 gene in humans. Mutation in this gene is associated with Treacher Collins syndrome (TCS), the most common and well-known mandibulofacial dysostosis. It is an autosomal dominant craniofacial disorder characterised by midface hypoplasia, micrognathia, downslanting palpebral fissures, eyelid colobomata and ear deformities.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

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Maria A Brehm et al.
Journal of cell science, 126(Pt 2), 437-444 (2012-12-04)
Fundamental to the life and destiny of every cell is the regulation of protein synthesis through ribosome biogenesis, which begins in the nucleolus with the production of ribosomal RNA (rRNA). Nucleolar organization is a highly dynamic and tightly regulated process;
Chiara Conte et al.
BMC medical genetics, 12, 125-125 (2011-09-29)
Treacher Collins syndrome (TCS) is one of the most severe autosomal dominant congenital disorders of craniofacial development and shows variable phenotypic expression. TCS is extremely rare, occurring with an incidence of 1 in 50.000 live births. The TCS distinguishing characteristics
Jan-Ulrich Schlump et al.
European journal of pediatrics, 171(11), 1611-1618 (2012-06-26)
Treacher Collins syndrome (TCS) is the most common and well-known mandibulofacial dysostosis caused by mutations in at least three genes involved in pre-rRNA transcription, the TCOF1, POLR1D and POLR1C genes. We present a severely affected male individual with TCS with
Michael Bowman et al.
European journal of human genetics : EJHG, 20(7), 769-777 (2012-02-10)
Treacher-Collins-Franceschetti syndrome (TCS) is an autosomal dominant craniofacial disorder characterised by midface hypoplasia, micrognathia, downslanting palpebral fissures, eyelid colobomata, and ear deformities that often lead to conductive deafness. A total of 182 patients with signs consistent with a diagnosis of

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