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GW22489

Sigma-Aldrich

Anti-GNAI3 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-87U6, Anti-ARCND1, Anti-HG1A

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

chicken

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human, mouse, rat

Hersteller/Markenname

Genway 15-288-22489

Methode(n)

immunocytochemistry: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NP_006487.1

UniProt-Hinterlegungsnummer

P08754

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... GNAI3(2773)

Verwandte Kategorien

Immunogen

Immunogen Sequence: GI # 5729850, sequence 345-353
Synthetic peptide sequence of guanine nucleotide binding protein (G protein), α inhibiting activity polypeptide 3.

Anwendung

Anti-GNAI3 antibody produced in chicken is suitable for immunocytochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Guanine nucleotide-binding protein G(k) subunit α is a protein encoded by the GNAI3 gene in humans. It is composed of α, β and γ subunits and mediates hormonal regulation of many membrane functions. GNAI3 subunit translocations to the cytoskeleton and its simultaneous inhibition indicates that the cytoskeleton might participate in the signaling process of human epithelial cells.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

S Y Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(12), 4153-4157 (1988-06-01)
The guanine nucleotide-binding proteins (G proteins), which mediate hormonal regulation of many membrane functions, are composed of alpha, beta, and gamma subunits. We have cloned and characterized cDNA from a human T-cell library encoding a form of alpha i that
Anil Akturk et al.
Science advances, 8(42), eabq2826-eabq2826 (2022-10-20)
Inhibitory G proteins (GNAI/Gαi) bind to the scaffold G protein signaling modulator 2 (GPSM2) to form a conserved polarity complex that regulates cytoskeleton organization. GPSM2 keeps GNAI in a guanosine diphosphate (GDP)-bound state, but how GPSM2-GNAI is generated or relates
J L Adolfsson et al.
Biochemical and biophysical research communications, 226(2), 413-419 (1996-09-13)
The present results show that stimulation of Intestine 407 epithelial cells with LTD4 (Leukotriene D4) triggers a rapid activation of the pertussis-toxin-sensitive Gi3-protein and a simultaneous translocation of its alpha-subunits to a crude cytoskeletal fraction. The activation of G alpha
Katie S Kindt et al.
Nature communications, 12(1), 2861-2861 (2021-05-19)
Hair cells detect sound, head position or water movements when their mechanosensory hair bundle is deflected. Each hair bundle has an asymmetric architecture that restricts stimulus detection to a single axis. Coordinated hair cell orientations within sensory epithelia further tune

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