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E4132

Sigma-Aldrich

1,N6-Etheno-2′-deoxyadenosine

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About This Item

Empirische Formel (Hill-System):
C12H13N5O3
CAS-Nummer:
68498-25-9
Molekulargewicht:
275.26
MDL-Nummer:
MFCD00056769
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24894542

Form

solid

Lagertemp.

−20°C

SMILES String

OCC1OC(CC1O)n2cnc3c2ncn4ccnc34

InChI

1S/C12H13N5O3/c18-4-8-7(19)3-9(20-8)17-6-14-10-11-13-1-2-16(11)5-15-12(10)17/h1-2,5-9,18-19H,3-4H2

InChIKey

XQQIMTUYVDUWKJ-UHFFFAOYSA-N

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Mayura Meerang et al.
Free radical biology & medicine, 44(10), 1863-1868 (2008-03-18)
Thalassemic diseases including homozygous beta-thalassemia and beta-thalassemia/Hb E (beta-Thal/Hb E) are prevalent in Southeast Asia. Iron overload is a common complication in beta-thalassemia patients which induces intracellular oxidative stress and lipid peroxidation (LPO). LPO end products generate miscoding etheno adducts
Jagadeesan Nair et al.
Biochemical and biophysical research communications, 336(2), 478-482 (2005-09-03)
Reactive oxygen species (ROS) and lipid peroxidation (LPO) play a role in aging and degenerative diseases. To correlate oxidative stress and LPO-derived DNA damage, we determined etheno-DNA-adducts in liver and brain from ROS overproducing OXYS rats in comparison with age-matched
Plamen P Christov et al.
Chemical research in toxicology, 23(8), 1330-1341 (2010-06-29)
Oligonucleotides were synthesized containing the 7-(2-oxoheptyl)-etheno-dGuo adduct, which is derived from the reaction of dGuo and the lipid peroxidation product 4-oxo-2-nonenal. The in vitro replication of 7-(2-oxoheptyl)-etheno-dGuo by the model Y-family polymerase Sulfolobus solfataricus P2 DNA Polymerase IV (Dpo4) was
Deepak T Nair et al.
Nature structural & molecular biology, 13(7), 619-625 (2006-07-05)
The 1,N6-ethenodeoxyadenosine (epsilon dA) lesion is promutagenic and has been implicated in carcinogenesis. We show here that human Pol iota, a Y-family DNA polymerase, can promote replication through this lesion by proficiently incorporating a nucleotide opposite it. The structural basis
Poh-Gek Forkert et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(5), 713-720 (2007-02-14)
Vinyl carbamate (VC) is derived from ethyl carbamate, a carcinogen formed in fermentation of food and alcoholic products. We have undertaken studies to test the hypothesis that an epoxide generated from VC oxidation leads to formation of 1,N6-ethenodeoxyadenosine (epsilon dAS).
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