C4695

CHAPSO

BioXtra

• Synonym(e): 3-([3-Cholamidopropyl]dimethylammonio)-2-hydroxy-1-propansulfonat
• Empirische Formel (Hill-System): C₃₂H₅₈N₂O₈S
• CAS-Nummer: 82473-24-3
• Molekulargewicht: 630.88
• Beilstein: 5842642
• MDL-Nummer: MFCD00081079
• UNSPSC-Code: 12161900
• PubChem Substanz-ID: 24892713
• NACRES: NA.25

Eigenschaften

• Beschreibung: zwitterionic
• Produktlinie: BioXtra
• Assay: ≥98.0% (TLC)
• Form: powder
• Mol-Gew.: micellar avg mol wt 7000
• Aggregatnummer: 11
• Verunreinigungen: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• Glührückstand: ≤0.1%
• CMC: 8 mM (20-25°C); 8 mM (micellar weight =9960)
• mp (Schmelzpunkt): 184-186 °C (lit.)
• Übergangstemp.: cloud point 90 °C
• Löslichkeit: H₂O: 0.1 M, clear, colorless
• Anionenspuren: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• Kationenspuren: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.01%; Pb: ≤0.001%; Zn: ≤0.0005%
• SMILES String: [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(=O)NCCC[N+](C)(C)CC(O)CS([O-])(=O)=O
• InChI: 1S/C32H58N2O8S/c1-20(7-10-29(39)33-13-6-14-34(4,5)18-23(36)19-43(40,41)42)24-8-9-25-30-26(17-28(38)32(24,25)3)31(2)12-11-22(35)15-21(31)16-27(30)37/h20-28,30,35-38H,6-19H2,1-5H3,(H-,33,39,40,41,42)/t20-,21+,22-,23?,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
• InChIKey: GUQQBLRVXOUDTN-XOHPMCGNSA-N

Beschreibung

Allgemeine Beschreibung

Chapso is a zwitterionic detergent derived from Chaps by the addition of a functional hydroxyl group. It is a nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group.

Anwendung

Chapso has been used in a study to assess methods for high-throughput crystallization of membrane proteins. It has also been used in a study to investigate the effects of detergents on the structure of rhomboid proteases in a lipid environment.

Ein nicht denaturierendes, zwitterionisches Detergens mit ähnlichen Eigenschaften wie CHAPS, das jedoch aufgrund einer stärker polaren Kopfgruppe besser löslich ist. Für die Solubilisierung von integralen Membranproteinen geeignet.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves