C1494

Carmofur

≥98% (HPLC), powder

• Synonym(e): 1-Hexylcarbamoyl-5-fluorouracil, HCFU
• Empirische Formel (Hill-System): C₁₁H₁₆FN₃O₃
• CAS-Nummer: 61422-45-5
• Molekulargewicht: 257.26
• MDL-Nummer: MFCD00866284
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329774890
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >15 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
• InChI: 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
• InChIKey: AOCCBINRVIKJHY-UHFFFAOYSA-N

Beschreibung

Anwendung

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells.[1] It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine [2].

Biochem./physiol. Wirkung

Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1).[3][4] Carmofur has a therapeutic activity against colorectal and cervical cancer.[5][4] It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (M^pro) in vitro.[5]

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Carmofur is an antineoplastic agent and a flurorouracil analog.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H361
• P-Sätze: P201 - P301 + P310 + P330
• Gefahreneinstufungen: Acute Tox. 3 Oral - Repr. 2
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable