C1244

CHM-1 hydrate

≥99% (HPLC), solid

• Synonym(e): 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158
• Empirische Formel (Hill-System): C₁₆H₁₀FNO₃ · xH₂O
• CAS-Nummer: 154554-41-3
• Molekulargewicht: 283.25 (anhydrous basis)
• MDL-Nummer: MFCD11114577
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329774746
• NACRES: NA.77

Eigenschaften

• Assay: ≥99% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Löslichkeit: DMSO: ≥5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: O.Fc1ccccc1C2=CC(=O)c3cc4OCOc4cc3N2
• InChI: 1S/C16H10FNO3.H2O/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12;/h1-7H,8H2,(H,18,19);1H2
• InChIKey: KIAVGSCBJYDTIM-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

CHM-1 possess antimitotic,antiangiogenic and antitumor activity. It is a potent and selective antitumor agent in human hepatocellular carcinoma. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization.

Leistungsmerkmale und Vorteile

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)