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C1241
Anti-Calcium Channel CaV1.2 (human) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Anti-Calcium Channel CaV1.2 (human) antibody produced in rabbit
Synonym(s):
Anti-Human α1C, L-Type of Voltage-gated Calcium Channel
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| Size/SKU | Availability | Price |
|---|---|---|
200 μL | Check Cart for Availability | $952.00 |
About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, WB
Citations:
4
$952.00
Check Cart for Availability
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, mouse, rat
technique(s)
immunocytochemistry: suitable, western blot: 1:200 using rat heart membranes
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CACNA1C(775)
mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)
General description
Calcium Channel CaV1.2 (CACNA1C ) encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization.
Immunogen
peptide corresponding to residues 2-15 of human Cav1.2 (exon 1B). The sequence has 14/15 residues identical in mouse and rat.
Biochem/physiol Actions
Calcium channel, voltage-dependent, L type, α1C subunit (Cav1.2) is a protein encoded by the CACNA1C gene in humans and belongs to the family of voltage-gated calcium channels. It serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate different physiological events. CACNA1C is a subunit of L-type voltage-dependent calcium channel. It is mapped to chromosome 12p13.3 and is implicated as a susceptibility gene for schizophrenia. CACNA1C is selectively expressed in human TH2 cells and blockage of Cav1.2 channel activation in TH2 cells may represent new strategies to treat allergic diseases in human subjects. Its increased activity is implicated in the pathogenesis of dementia and Alzheimer′s disease (AD).
Recognizes mouse Cav1.2, splice variants P22002-4 and P22002-5 of rat Cav1.2 and splice variant P15381-4 of rabbit Cav1.2.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, with 1% BSA and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| Gene Information human ... CACNA1C(775) | Gene Information human ... KCNQ1(3784) | Gene Information human ... KCNA3(3738) | Gene Information human ... CACNA1D(776) |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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