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B8562

BD 1047 dihydrobromide

≥95% (HPLC)

Synonym(e):

BD 1047 dihydrobromide

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Über diesen Artikel

Empirische Formel (Hill-System):
C13H20Cl2N2 · 2 HBr
CAS-Nummer:
138356-21-5
Molekulargewicht:
437.04
NACRES:
NA.77
PubChem Substance ID:
329773309
UNSPSC Code:
12352200
MDL number:
MFCD00792739
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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Unterstützung erhalten

Quality Level

100

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: >5 mg/mL

storage temp.

2-8°C

SMILES string

Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1

InChI

1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H

InChI key

WOALTFHGLDVJHK-UHFFFAOYSA-N

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Dieser Artikel
P0618I135I4034
BD 1047 dihydrobromide ≥95% (HPLC)

Sigma-Aldrich

B8562

BD 1047 dihydrobromide

cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide ≥98% (HPLC), solid

Sigma-Aldrich

P0618

cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide

Imetit dihydrobromide ≥98% (HPLC)

Sigma-Aldrich

I135

Imetit dihydrobromide

Immepip dihydrobromide ≥97% (HPLC), powder

Sigma-Aldrich

I4034

Immepip dihydrobromide

form

powder

form

solid

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: >5 mg/mL

solubility

H2O: soluble ~10 mg/mL at 60 °C (Sonicate), DMSO: soluble 12 mg/mL

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 10 mg/mL, clear

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

desiccated

Application

BD 1047 dihydrobromide has been used as an antagonist of sigma-1 receptor in hepatocellular carcinoma cells.[1]
BD 1047, a selective, putative σ1 receptor antagonist, is used in sigma receptor research to help differentiate and characterized the function and role of the sigma1 receptor versus other sigma receptor subtypes. BD 1047 is used to help define the role of σ1 receptors in neurological processes.

Biochem/physiol Actions

BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity.
BD-1047 is a selective, putative σ receptor antagonist with antidystonic activity. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- & α2-adrenoceptor, 5-HT1, and 5-HT2. Though s receptor antagonism is consistent with antipsychotic, especially anti-schizophrenic, activity, BD-1047 shows only modest activity in animal screens for antipsychotics.
In human immunodeficiency (HIV)-1 seropositive patients, BD 1047 along with other antioxidants may aid in reduction of cathepsin B- based neuropathology.[2]

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000535971
0000535971
0000465073
0000465073
0000198213

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Die Dokumentenbibliothek aufrufen

Tao Bai et al.
Journal of cellular and molecular medicine, 23(11), 7349-7359 (2019-09-12)
Sigma-1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2-related factor 2 (NRF2), which plays a vital role in ferroptosis. Sorafenib is a strong inducer of ferroptosis but not of apoptosis. However, the mechanism of sorafenib-induced
Omar Vélez López et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 14(2), 226-240 (2018-10-12)
Pathogenesis of HIV-associated neurocognitive disorders (HAND) is mediated through the infiltration of perivascular macrophages into the brain with the secretion of viral, neurotoxic and inflammatory proteins. One of these proteins is cathepsin B (CATB), a lysosomal cysteine protease that induces
Susmita Sil et al.
Molecular neurobiology, 56(5), 3576-3590 (2018-08-29)
Cocaine, a known psychostimulant, results in oxidative stress and inflammation. Recent studies from our group have shown that cocaine induces inflammation in glial cells. Our current study was aimed at investigating whether cocaine exposure could also induce inflammation in non-glial

Global Trade Item Number

SKUGTIN
B8562-5MG04061833228555
B8562-25MG04061833228548

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