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Merck

B5399

(±)-Baclofen

≥98% (HPLC), GABAB receptor agonist, solid

Synonym(e):

(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal

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500 MG

€ 67,40

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€ 284,75

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Über diesen Artikel

Empirische Formel (Hill-System):
C10H12ClNO2
CAS-Nummer:
1134-47-0
Molekulargewicht:
213.66
NACRES:
NA.32
PubChem Substance ID:
24278146
UNSPSC Code:
12352200
EC Number:
214-486-9
MDL number:
MFCD00055143
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

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Produktname

(±)-Baclofen, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white to very faintly yellow

solubility

1 M HCl: 50 mg/mL

storage temp.

2-8°C

SMILES string

ClC1=CC=C(C(CN)CC(O)=O)C=C1

InChI

1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

InChI key

KPYSYYIEGFHWSV-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

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Dieser Artikel
G013A6566S166
(±)-Baclofen ≥98% (HPLC), solid

Sigma-Aldrich

B5399

(±)-Baclofen

R(+)-Baclofen hydrochloride solid

Sigma-Aldrich

G013

R(+)-Baclofen hydrochloride

2-Hydroxysaclofen ≥98% (TLC), solid

Sigma-Aldrich

A6566

2-Hydroxysaclofen

Saclofen solid

Sigma-Aldrich

S166

Saclofen

assay

≥98% (HPLC)

assay

-

assay

≥98% (TLC)

assay

-

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

solubility

1 M HCl: 50 mg/mL

solubility

DMSO: >20 mg/mL, H2O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.)

solubility

H2O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL

solubility

0.1 M NaOH: 20 mg/mL

color

white to very faintly yellow

color

white

color

white

color

white

Application

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABAB receptor agonist:
  • as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity[1]
  • to test its effects on in vivo motor function tests and performance of mutant mice[2]
  • to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)[3]
  • to test its effect in reducing dendritic excitability in Purkinje neurons[4]

Biochem/physiol Actions

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties [1] Being a γ-aminobutyric acid receptor B (GABAB) agonist, baclofen may be involved in the potentiation of dendritic potassium K+ channels.[4] It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD).[5] Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).[6]
GABAB receptor agonist; skeletal muscle relaxant; antispastic agent.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCM1785
BCCJ6574
BCCF9709
BCCD7786
BCBZ2936

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Die Dokumentenbibliothek aufrufen

The effects of baclofen for the treatment of gastroesophageal reflux disease: a meta-analysis of randomized controlled trials.
Li, et al.
Gastroenterology Research and Practice, 2014, 307805-307805 (2020)
The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective.
de Beaurepaire, et al.
Frontiers in Psychiatry, 9, 708-708 (2021)
Abhiram Pushparaj et al.
Behavioural brain research, 290, 77-83 (2015-05-03)
Our prior work demonstrated the involvement of the caudal granular subregion of the insular cortex in a rat model of nicotine self-administration. Recent studies in various animal models of addiction for nicotine and other drugs have identified a role for
Mohamed-Ali Gorsane et al.
Substance abuse, 33(4), 336-349 (2012-09-20)
Baclofen, a γ-aminobutyric acid (GABA)-B receptor agonist, represents a promising drug in alcohol addiction management. Animal models have shown its action at various stages of the process of alcohol addiction. Moreover, initial open and randomized controlled trials have shown the
Ravi Chopra et al.
PloS one, 13(5), e0198040-e0198040 (2018-05-31)
Purkinje neuron dendritic degeneration precedes cell loss in cerebellar ataxia, but the basis for dendritic vulnerability in ataxia remains poorly understood. Recent work has suggested that potassium (K+) channel dysfunction and consequent spiking abnormalities contribute to Purkinje neuron degeneration, but
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Verwandter Inhalt

Product Information Sheet - B5399

Product Information Sheet

Global Trade Item Number

SKUGTIN
B5399-10G04061833002162
B5399-500MG04061833433829
B5399-5G04061833433836

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