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Merck

B0385

Beclomethason

≥99%, anti-inflammatory agent, powder

Synonym(e):

9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione

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100 MG

€ 215,00

250 MG

€ 470,00

1 G

€ 1.280,00

€ 215,00


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Über diesen Artikel

Empirische Formel (Hill-System):
C22H29ClO5
CAS-Nummer:
Molekulargewicht:
408.92
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
224-585-9
MDL number:
Assay:
≥99%
Form:
powder
Quality level:

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Unterstützung erhalten

Produktname

Beclomethason, ≥99%

assay

≥99%

form

powder

InChI

1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12?,15?,16?,17?,19?,20?,21-,22?/m0/s1

InChI key

NBMKJKDGKREAPL-WOOYFSPWSA-N

SMILES string

[H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C

originator

GlaxoSmithKline

storage temp.

2-8°C

Quality Level

Gene Information

human ... CYP1A2(1544)

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Dieser Artikel
B0515D1756P8650
form

powder

form

powder

form

powder

form

powder

assay

≥99%

assay

-

assay

≥98% (HPLC)

assay

≥97%

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

originator

GlaxoSmithKline

originator

Schering Plough

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

-

Gene Information

human ... CYP1A2(1544)

Gene Information

-

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Gene Information

human ... NR3C1(2908)

Application

Beclomethasone has been used in MS−MS (mass spectrometry) methods for the analysis of β-agonists, corticosteroids, chloramphenicol and penicillins.[1] It has also been used to find the differential response of glucocorticoids in larval regeneration model.[2]

Biochem/physiol Actions

Beclomethasone is an anti-inflammatory glucocorticoid.
It helps to decrease airway hyperresponsiveness. It also helps to regulate symptoms of asthma.[3]

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Die Dokumentenbibliothek aufrufen

A comparison of beclomethasone, salmeterol, and placebo in children with asthma
Simons, FER, et al.
The New England Journal of Medicine, 337(23), 1659-1665 (1997)
Hong Ping Zhang et al.
Allergy and asthma proceedings, 35(4), 278-287 (2014-07-06)
It has proven efficacy in reducing asthma exacerbations, but the effect size of montelukast (a leukotriene receptor antagonist) for varied severity of asthma exacerbations is not systematically assessed. This study was designed to systematically explore the evidence for montelukast, as
Antonia Chatzopoulou et al.
Molecular and cellular endocrinology, 447, 61-70 (2017-03-01)
In humans, two splice variants of the glucocorticoid receptor (GR) exist: the canonical α-isoform, and the β-isoform, which has been shown to have a dominant-negative effect on hGRα. Previously, we have established the occurrence of a GR β-isoform in zebrafish
Lydia J Finney et al.
The Journal of allergy and clinical immunology, 147(2), 510-519 (2020-10-18)
The mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled corticosteroids (ICSs) are widely used in COPD, but the extent
Yufei Xie et al.
Disease models & mechanisms, 12(5) (2019-05-11)
Glucocorticoid drugs are widely used to treat immune-related diseases, but their use is limited by side effects and by resistance, which especially occurs in macrophage-dominated diseases. In order to improve glucocorticoid therapies, more research is required into the mechanisms of

Artikel

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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