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MilliporeSigma

A9950

Sigma-Aldrich

Aniracetam

≥98%

Synonym(e):

1-(4-Methoxybenzoyl)-2-pyrrolidinone, Ro 13-5057

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10 MG
$25.30
25 MG
$33.35
50 MG
$48.30
100 MG
$74.75
250 MG
$147.20
1 G
$370.30
5 G
$1,322.50

Lieferanten-SKU: A302163-10MG

$25.30


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10 MG
$25.30
25 MG
$33.35
50 MG
$48.30
100 MG
$74.75
250 MG
$147.20
1 G
$370.30
5 G
$1,322.50

About This Item

Empirische Formel (Hill-System):
C12H13NO3
CAS-Nummer:
Molekulargewicht:
219.24
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Lieferanten-SKU: A302163-10MG

$25.30


Versand in 7 Tagen - ab Aldrich Partner.

Assay

≥98%

Ersteller

Roche

SMILES String

COc1ccc(cc1)C(=O)N2CCCC2=O

InChI

1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3

InChIKey

ZXNRTKGTQJPIJK-UHFFFAOYSA-N

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Anwendung

Aniracetam has been used in the inhibition screening assays for kinase enzyme.[1]

Biochem./physiol. Wirkung

Aniracetam is a piracetam analog and has low bioavailability due to rapid excretion.[2] It enhances the cognitive thinking and is effective for treatment of sleep and behavioral disorders.[3] Aniracetam is prescribed for anxiety and also enhances learning and memory in situations with induced damage of the brain.[4]
Cognition enhancer (nootropic) that potentiates AMPA receptor mediated ion conductance and potentiates metabotropic glutamate receptor activity.

Leistungsmerkmale und Vorteile

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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T H Johansen et al.
Molecular pharmacology, 48(5), 946-955 (1995-11-01)
We examined the actions of cyclothiazide, aniracetam, and 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI-52466) on recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and kainate receptors. Receptors expressed in Xenopus oocytes or human embryonic kidney 293 cells were characterized using voltage and patch-clamp electrophysiology. Aniracetam and cyclothiazide potentiated
Sensitive and selective liquid chromatography-tandem mass spectrometry method for the quantification of aniracetam in human plasma.
Zhang J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 858(1-2), 129-134 (2007)
Rudolf Mueller et al.
Bioorganic & medicinal chemistry letters, 21(13), 3927-3930 (2011-06-04)
AMPA receptors (AMPARs) are an important therapeutic target in the CNS. A series of substituted benzoxazinone derivatives with good to very good in vitro activity as positive allosteric AMPAR modulators was synthesized and evaluated. The appropriate substituent choice on the
Nayana Wijayawardhane et al.
Neurobiology of disease, 26(3), 696-706 (2007-05-12)
Aniracetam is a nootropic compound and an allosteric modulator of AMPA receptors (AMPARs) which mediate synaptic mechanisms of learning and memory. Here we analyzed impairments in AMPAR-mediated synaptic transmission caused by moderate prenatal ethanol exposure and investigated the effects of
Hua Yang et al.
Journal of neurophysiology, 99(5), 2510-2521 (2008-03-28)
Several mechanisms can underlie short-term synaptic depression, including vesicle depletion, receptor desensitization, and changes in presynaptic release probability. To determine which mechanisms affect depression under physiological conditions, we studied the synapse formed by auditory nerve fibers onto bushy cells in

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