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A5686

Arg-Gly-Glu-Ser acetate salt

≥95% (HPLC)

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Über diesen Artikel

Empirische Formel (Hill-System):
C16H29N7O8
CAS-Nummer:
Molekulargewicht:
447.44
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Form:
powder
Assay:
≥95% (HPLC)
Biological source:
synthetic (organic)

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Unterstützung erhalten

biological source

synthetic (organic)

Quality Level

assay

≥95% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(O)=O.N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O

InChI

1S/C16H29N7O8.C2H4O2/c17-8(2-1-5-20-16(18)19)13(28)21-6-11(25)22-9(3-4-12(26)27)14(29)23-10(7-24)15(30)31;1-2(3)4/h8-10,24H,1-7,17H2,(H,21,28)(H,22,25)(H,23,29)(H,26,27)(H,30,31)(H4,18,19,20);1H3,(H,3,4)/t8-,9-,10-;/m0./s1

InChI key

SALKOFBHHIHLSW-PUBMXKGKSA-N

Gene Information

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

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Dieser Artikel
A6677A8052ECM001
assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (TLC)

assay

≥95% (SDS-PAGE)

biological source

synthetic (organic)

biological source

synthetic (organic
organic)

biological source

synthetic

biological source

human

form

powder

form

powder

form

powder

form

lyophilized powder

Gene Information

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

Gene Information

human ... FN1(2335)

Gene Information

human ... FN1(2335)

Gene Information

human ... FN1(2335)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Application

Arg-Gly-Glu-Ser acetate salt has been used:
  • as an integrin blocking peptide to study its effects on ciliary neurotrophic factor (CNTF) regulation in astroglioma cells[1]
  • as a control peptide to study its effects on the binding of patient IgG to integrin αvβ6[2]
  • as an integrin inhibitor peptide to study its effects on cell adhesion in Capsaspora owczarzaki cells[3]

Biochem/physiol Actions

Arg-Gly-Glu-Ser peptide acts as an integrin-blocking peptide.[1]
Inhibitor of platelet aggregation

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Die Dokumentenbibliothek aufrufen

Helena Parra-Acero et al.
Current biology : CB, 30(21), 4270-4275 (2020-08-29)
In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors mediating cell-matrix adhesion in animals. They are heterodimeric transmembrane proteins that
Seong Su Kang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(27), 9277-9287 (2012-07-06)
Ciliary neurotrophic factor (CNTF) is a potent neural cytokine with very low expression in the CNS, predominantly by astrocytes. CNTF increases rapidly and greatly following traumatic or ischemic injury. Understanding the underlying mechanisms would help to design pharmacological treatments to
Changsuk Moon et al.
Respiratory research, 10, 18-18 (2009-03-11)
Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory responses to intratracheal (i.t.) lipopolysaccharide (LPS) treatment and on the integrin signaled mitogen-activated protein
Gartner, T.K., et al.
Blood, 66, 305a-305a (1985)
Hiroyuki Yoshida et al.
Journal of gastroenterology, 58(8), 778-789 (2023-06-13)
Patients with primary sclerosing cholangitis (PSC) possess autoantibodies against biliary epithelial cells. However, the target molecules remain unknown. The sera of patients with PSC and controls were subjected to enzyme-linked immunosorbent assays to detect autoantibodies using recombinant integrin proteins. Integrin

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