The stability of this product in solution is not determined. However, similar product F3506 states that solutions of N-Formyl-Met-Leu-Phe can be stored, in aliquots, at -20°C for at least six months.
47729
N-Formyl-Met-Leu-Phe
≥99.0% (TLC), BioXtra
Synonym(e):
Chemotaktisches Peptid, N-Formyl-L-methionyl-L-leucyl-L-phenylalanin, fMLP (misnomer but widely used)
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Über diesen Artikel
Empirische Formel (Hill-System):
C21H31N3O5S
CAS-Nummer:
Molekulargewicht:
437.55
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
2315783
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Unterstützung erhaltenProduktname
N-Formyl-Met-Leu-Phe, BioXtra, ≥99.0% (TLC)
InChI
1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
SMILES string
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
InChI key
PRQROPMIIGLWRP-BZSNNMDCSA-N
product line
BioXtra
assay
≥99.0% (TLC)
form
powder
color
white
solubility
DMF: 50 mg/mL, clear, colorless
application(s)
cell analysis
storage temp.
2-8°C
Quality Level
Gene Information
human ... FPR1(2357)
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Verwandte Kategorien
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form powder | form - |
| assay ≥99.0% (TLC) | assay ≥97% (HPLC) | assay ≥98% (TLC) | assay 98% |
| product line BioXtra | product line - | product line - | product line - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMF: 50 mg/mL, clear, colorless | solubility acetic acid: 20 mg/mL, clear, colorless | solubility - | solubility - |
| color white | color - | color white | color - |
Application
1. 4th and 5th applications do not have access
2. 3rd application is not relevant
2. 3rd application is not relevant
Biochem/physiol Actions
Potentes chemotaktisches Peptid. Induziert einen metabolischen Burst in Makrophagen, zusammen mit einer Steigerung der Atemfrequenz, Sekretion von lysosomalen Enzymen und Produktion von Superoxidanion.
N-Formyl-Met-Leu-Phe is a potent chemotactic peptide and formyl peptide receptor (FPR) agonist that induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Astrid L Voskamp et al.
The journal of allergy and clinical immunology. In practice, 3(2), 192-199 (2015-02-03)
Allergic bronchopulmonary aspergillosis (ABPA) often presents with persistently uncontrolled asthma despite the use of corticosteroids and antifungal therapy. Omalizumab is a humanized anti-IgE monoclonal antibody currently used to treat severe asthma. The aim was to assess the clinical and immunologic
C Dahlgren et al.
Blood, 95(5), 1810-1818 (2000-02-26)
A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology.
J James B Edelman et al.
Shock (Augusta, Ga.), 39(2), 149-154 (2013-01-18)
Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without
Alexandra F Santos et al.
The Journal of allergy and clinical immunology, 134(3), 645-652 (2014-07-30)
Most of the peanut-sensitized children do not have clinical peanut allergy. In equivocal cases, oral food challenges (OFCs) are required. However, OFCs are laborious and not without risk; thus, a test that could accurately diagnose peanut allergy and reduce the
Karama Makni-Maalej et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4657-4665 (2012-09-25)
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The
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How long can this product be stored at -20 when reconstituted in DMSO?
1 answer-
Helpful?
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What is the solubility of the product 47729, N-Formyl-Met-Leu-Phe?
1 answer-
Product is soluble in water (partly), methanol, DMSO (4 mg/ml), ethanol (2 mg/ml), and DMF (Dimethylformamide) (50 mg/ml).
Helpful?
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Can this product be dissolved in DMSO?
1 answer-
Yes, this product can be solubilized in DMSO. The exact concentration at which it may be solubilized is not determined. However, several sources state that it is soluble in DMSO at 30 mg/mL.
Helpful?
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