33899

Norfloxacin

VETRANAL^®, analytical standard

• Synonym(e): 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsäure, 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-3-chinolincarbonsäure
• Empirische Formel (Hill-System): C₁₆H₁₈FN₃O₃
• CAS-Nummer: 70458-96-7
• Molekulargewicht: 319.33
• NACRES: NA.24
• PubChem Substance ID: 329754535
• UNSPSC Code: 41116107
• EC Number: 274-614-4
• MDL number: MFCD00079532

Eigenschaften

• grade: analytical standard
• Quality Segment: 100
• agency: EPA 1694
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3
• InChI: 1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
• InChI key: OGJPXUAPXNRGGI-UHFFFAOYSA-N

Beschreibung

General description

Norfloxacin is an antimicrobial drug, belonging to the class of fluoroquinolones (FQs), which shows broad-spectrum activity against a wide range of Gram-negative and Gram-positive organisms.

Application

Norfloxacin may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations, biological fluids and sewage using various chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Norfloxacin blockiert die DNA-Replikation durch Wechselwirkung mit einer ATP-induzierten strukturellen Transition der mit DNS-Gyrase (Topoisomerase) komplexierten DNA.
Wirkungsweise: hemmt die bakterielle DNA-Replikation
Antimikrobielles Spektrum: Gram-negative Bakterien, weniger effektiv bei Gram-positiven Bakterien

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)