Cycloheximide is commonly used to block protein synthesis in eukaryotic cells and in ribosome profiling experiments. It is recommended to refer to literature for further information, for example: https://pmc.ncbi.nlm.nih.gov/articles/PMC2831214/ and https://www.nature.com/articles/s41467-021-25411-y.
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18079
Cycloheximid -Lösung
0.1%, suitable for microbiology
Synonym(e):
CHX
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 10 x 10 mL | Ab HEUTE lieferbarvonSchnelldorf | € 149,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C15H23NO4
CAS-Nummer:
Molekulargewicht:
281.35
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
41171614
MDL number:
Technischer Dienst
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Unterstützung erhaltensterility
sterile (Filtered and Aseptic Handled)
Quality Segment
form
liquid
shelf life
limited shelf life, expiry date on the label
concentration
0.1%
antibiotic activity spectrum
fungi
application(s)
environmental
food and beverages, microbiology
storage temp.
2-8°C
suitability
bacteria
SMILES string
O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
Gene Information
human ... FKBP1A(2280), PIN1(5300)
General description
Cycloheximide solution is a selective supplement, that is safer and easier to use than cycloheximide powder. The required volume can be simply added to the medium before or after sterilization.
Application
Cycloheximide solution has been used as a supplement in De Man, Rogosa and Sharpe (MRS) and GM-17 agar plates to study its effects on lactic acid bacteria (LAB).
Biochem/physiol Actions
Cycloheximide solution is used to block the protein synthesis for suppressing the growth of fungi.
Physical form
Steril filtrierte Lösung, enthält 0.1% Cycloheximid
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Dieser Artikel | |||
|---|---|---|---|
| application(s) environmental | application(s) - | application(s) - | application(s) - |
| suitability bacteria | suitability - | suitability - | suitability - |
| form liquid | form ready-to-use solution | form powder | form powder or crystals |
| sterility sterile (Filtered and Aseptic Handled) | sterility - | sterility - | sterility - |
| shelf life limited shelf life, expiry date on the label | shelf life - | shelf life - | shelf life - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
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Lagerklasse
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Verwandter Inhalt
Xing Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(43), 15438-15443 (2014-10-16)
The receptor-interacting kinase-3 (RIP3) and its downstream substrate mixed lineage kinase domain-like protein (MLKL) have emerged as the key cellular components in programmed necrotic cell death. Receptors for the cytokines of tumor necrosis factor (TNF) family and Toll-like receptors (TLR)
Taichi Hara et al.
Scientific reports, 4, 6992-6992 (2014-11-12)
Peripheral myelin protein 22 (PMP22) resides in the plasma membrane and is required for myelin formation in the peripheral nervous system. Many PMP22 mutants accumulate in excess in the endoplasmic reticulum (ER) and lead to the inherited neuropathies of Charcot-Marie-Tooth
V O Kaminskyy et al.
Cell death & disease, 4, e522-e522 (2013-03-09)
TNF-related apoptosis-inducing ligand (TRAIL) is a promising cytokine for killing tumor cells. However, a number of studies have demonstrated that different cancer cells resist TRAIL treatment and, moreover, TRAIL can promote invasion and metastasis in resistant cells. Here we report
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 18079-10ML-F | 04061837399305 |
| 18079-10X10ML-F | 04061838110862 |
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Can be used for ribosomal profiling, as a blocker of protein synthesis in eukaryotic cells?
1 answer-
Helpful?
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I am looking to add this solution to a Lee's Multi Differential Agar (LMDS) media solution to prevent saccharomyces cerevisiae growth on my plates. How much of this cycloheximide solution should be added per 100 ml of LMDA agar media?
1 answer-
According to brewing industry experts, cycloheximide can be added to Lee's Multi Differential Agar in order to make the media selective to bacteria and wild yeast. With cycloheximide, one can suppress the growth of most brewing yeasts without interfering with bacteria and wild yeast growth. Concentrations recommended for this purpose are in the range from 7-10 mg/L. Adding 10 mLs of product 18079 (at a concentration of 0.1%) to 1 L of agar will result in a concentration of 10 mg/L (a 1:100 dilution).
Helpful?
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