MAB4306

Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

clone 4F7.2, Chemicon^®, from mouse

• Synonym(e): hLIF
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: 4F7.2, monoclonal
• Application: ELISA, WB
• Citations: 3

Eigenschaften

• biological source: mouse
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 4F7.2, monoclonal
• species reactivity: mouse, human
• manufacturer/tradename: Chemicon^®
• technique(s): ELISA: suitable, western blot: suitable
• input: sample type neural stem cell(s); sample type hematopoietic stem cell(s)
• isotype: IgG1
• NCBI accession no.: NM_002309.2
• UniProt accession no.: P15018
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... LIF(3976)

Beschreibung

General description

Leukemia inhibitory factor, or LIF, is a pleiotropic cytokine that is expressed by a wide variety of cells including activated T lymphocytes, monocytes, mast cells and neuronal cells. Human LIF cDNA encodes a 202 amino acid precursor which is processed to yield a 180 amino acid, biologically active glycoprotein with an approximate molecular weight of 38-67 kDa. In addition to its involvement in the stimulation of acute-phase protein during inflammatory processes, LIF has also been implicated in promoting the survival and growth of axons in vitro. LIF signals through the LIF receptor, a heterodimer comprised of a 190 kDa LIFR subunit and the gp130 subunit common to the IL-6, IL-11, CNTF and OSM receptors. Janus tyrosine kinases, JAK1 and JAK2, are activated in response to LIF stimulation, which in turn phosphorylate Stat1 and Stat3 causing their nuclear translocation and the transcription of Stat-responsive genes.

Application

Detect Human Leukemia Inhibitory Factor using this Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2 validated for use in ELISA & WB.

Research Category
Stem Cell Research

Research Sub Category
Pluripotent & Early Differentiation

Physical form

Format: Purified

Analysis Note

Control
Jurkat whole cell lysate

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable