MAB2609

Anti-beta Arrestin 1 Antibody, clone 3H11.2

clone 3H11.2, from mouse

• Synonym(e): Retinal S-antigen, Rod photoreceptor arrestin, S-antigen, retina and pineal gland (arrestin), arrestin 1, retinal S-antigen (48 KDa protein)
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: saturated ammonium sulfate (SAS) precipitated
• Antikörper-Produkttyp: primary antibodies
• Klon: 3H11.2, monoclonal
• Speziesreaktivität: human
• Methode(n): immunofluorescence: suitable; western blot: suitable
• Isotyp: IgMκ
• NCBI-Hinterlegungsnummer: NP_004032.2
• UniProt-Hinterlegungsnummer: P49407
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ARRB1(408)

Beschreibung

Allgemeine Beschreibung

The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).

Spezifität

Other species have not been tested.

Reacts with human beta-arrestin 1.

Immunogen

Epitope: a.a. 357-372

KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.

Anwendung

Research Category
Zellstruktur

Research Sub Category
Sensorik & Peripheres Nervensystem (PNS)

G-Proteine

Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.

Qualität

Evaluated on a representative lot by Western blot in HEK293 cell lysate.

Zielbeschreibung

~47 kDa

Physikalische Form

Format: Purified

Purified in PBS with 0.05% NaN3.

Lagerung und Haltbarkeit

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Hinweis zur Analyse

Control
HEK293 cell lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable