5.32586

AEBSF hydrochloride

≥99% (HPLC), powder, serine protease inhibitor, Calbiochem^®

• Synonym(e): AEBSF, HCl ≥99% by HPLC, 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride, HCl
• Empirische Formel (Hill-System): C₈H₁₀FNO₂S · xHCl
• CAS-Nummer: 30827-99-7
• Molekulargewicht: 203.23 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00132962
• Assay: ≥99% (HPLC)
• Form: powder
• Storage condition: OK to freeze, desiccated, protect from light

Eigenschaften

• Produktname: AEBSF, HCl ≥99% by HPLC,
• assay: ≥99% (HPLC)
• Quality Segment: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated, protect from light
• color: white
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: F[S](=O)(=O)c1ccc(cc1)CCN.[Cl-].[H+]
• InChI: 1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
• InChI key: WRDABNWSWOHGMS-UHFFFAOYSA-N

Beschreibung

General description

AEBSF >99%; 30827-99-7

Specific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K. A material with ≥97% purity by HPLC (Cat. No. 101500) & its InSolution is also available (Cat. No. 508436).Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
Serine proteases

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Citron, M., et al. 1996. Neuron17, 171.

Ohkubo, I., et al. 1994. J. Biochem.116, 1182.

Mintz, G.R. 1993. BioPharm.6, 34.

Lawson, W.B., et al. 1982. Folia Haematol.109, 52.

Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.
Markwardt, F., et al. 1973. Thromb. Res.2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Corrosive (L)

Sicherheitshinweise

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1A
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• Lagerklasse: 8A - Combustible corrosive hazardous materials