526521
PIM1 Inhibitor III
The PIM1 Inhibitor III controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(e):
PIM1 Inhibitor III
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C28H23N5O5Ru
Molekulargewicht:
610.58
UNSPSC-Code:
12352200
Empfohlene Produkte
Qualitätsniveau
Assay
≥95% (HPLC)
Form
solid
Hersteller/Markenname
Calbiochem®
Lagerbedingungen
OK to freeze
protect from light
Farbe
purple
Löslichkeit
DMSO: 6 mg/mL
Versandbedingung
wet ice
Lagertemp.
−20°C
Allgemeine Beschreibung
The racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
Biochem./physiol. Wirkung
Cell permeable: no
Primary Target
PIM1
PIM1
Product does not compete with ATP.
Reversible: no
Target IC50: 0.5 and 3 nM for the (S)- and (R)-enantiomer, of PIM-1, respectively
Verpackung
Packaged under inert gas
Warnhinweis
Toxicity: Standard Handling (A)
Rekonstituierung
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Sonstige Hinweise
Bergman, H. and Meggers, E., 2006. Org. Lett.8, 5465.
Rechtliche Hinweise
Sold for research purposes only, pursuant to an agreement with University of Pennsylvania.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Howard Bregman et al.
Organic letters, 8(24), 5465-5468 (2006-11-17)
Cyclopentadienyl half-sandwich ruthenium complexes have been demonstrated to be promising scaffolds as protein kinase inhibitors. In order to rapidly identify derivatives which display modified pharmacological properties, we developed the synthesis of an organoruthenium compound bearing an N-succinimidyl ester at the
Zhongde Ye et al.
NPJ aging and mechanisms of disease, 7(1), 4-4 (2021-02-10)
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