5.05823

Galectin-1 Antagonist, DB21

• Synonym(e): Galectin-1 Antagonist, DB21, SVQNvaKL-[DBF]-IIVKLNA
• Empirische Formel (Hill-System): C₈₃H₁₃₂N₁₈O₁₇
• Molekulargewicht: 1654.05
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: powder
• Wirksamkeit: 3 μM IC₅₀
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: DMSO: 10 mg/mL
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

Biochem./physiol. Wirkung

Primary Target
Galectin-1

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

SVQMKNva-[DBF]-IIVKLNA

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable