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860470P

Avanti

1-deoxysphingosine

Avanti Research™ - A Croda Brand 860470P, powder

Synonym(e):

1-deoxysphingosine (m18:1)

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About This Item

Empirische Formel (Hill-System):
C18H37NO
CAS-Nummer:
193222-34-3
Molekulargewicht:
283.49
UNSPSC-Code:
12352211
NACRES:
NA.25

Form

powder

Verpackung

pkg of 1 × 1 mg (860470P-1mg)
pkg of 1 × 10 mg (860470P-10mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 860470P

Lipid-Typ

bioactive lipids
sphingolipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

C[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC

Allgemeine Beschreibung

1-deoxysphingosine (1-deoxySO) has a (4E) double bond in its structure and is synthesized by the catabolism of 1-deoxyceramide in the presence of ceramidase enzyme. It is an unsaturated deoxy-sphingoid base.

Anwendung

1-deoxysphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing of MN9D dopaminergic neuroblastoma cell line and dorsal root ganglion neurons cultures. It may also be used as a standard for quantification of spingolipids from human plasma samples by liquid chromatography electrospray ionization tandem mass spectrometry (LC−ESI−MS/MS).

Biochem./physiol. Wirkung

1-deoxysphingosine levels are elevated in lymphoblasts in hereditary sensory neuropathy type 1 (HSAN1) disorder.

Verpackung

5 mL Amber Glass Screw Cap Vial (860470P-10mg)
5 mL Amber Glass Screw Cap Vial (860470P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Regula Steiner et al.
Journal of lipid research, 57(7), 1194-1203 (2016-05-12)
The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the rare inherited neuropathy, HSAN1, and diabetes type 2
Analysis of sphingolipids in extracted human plasma using liquid chromatography electrospray ionization tandem mass spectrometry
Bui HH, et al.
Analytical Biochemistry, 423(2), 187-194 (2012)
Elucidating the chemical structure of native 1-deoxysphingosine
Steiner R, et al.
Journal of Lipid Research, 57(7), 1194-1203 (2016)
M F Dohrn et al.
European journal of neurology, 22(5), 806-814 (2015-01-28)
Diabetic distal sensorimotor polyneuropathy (DSPN) is a frequent, disabling complication of diabetes mellitus. There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). Whether neurotoxic 1-deoxy-sphingolipids are elevated in DSPN patients' plasma and
Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
Martinez TN, et al.
Mol. Neurodegener., 7(1), 45-45 (2012)
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