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Merck

CRYGA

crystallin, gamma A

Synonyme:
CRY-g-A, CRYG1, CRYG5
Spezies:
Human CRYGA (1418), Mouse Cryga (12964), Rat Cryga (684028), domestic guinea pig Cryga (100337642), domestic cat CRYGA (101093630), dog CRYGA (488498), sheep CRYGA (101120055), cow CRYGA (538688), cow CRYGA (100335856)
UniProtKB-ID:
P11844, Q53ST5
Gen-ID:
  • Human(1418) Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]
  • Mouse(12964) crystallin, gamma A
  • Rat(684028) crystallin, gamma A
  • domestic guinea pig(100337642) crystallin, gamma A
  • domestic cat(101093630) crystallin, gamma A
  • dog(488498) crystallin, gamma A
  • sheep(101120055) crystallin, gamma A
  • cow(538688) crystallin, gamma A
  • cow(100335856) crystallin, gamma A

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Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
HPA043386
Anti-CRYGA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Speziesreaktivität
human
Anwendung
immunofluorescence
immunohistochemistry