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  • Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Annals of the New York Academy of Sciences (2014-04-05)
Alina Fedoseienko, Paulina Bartuzi, Bart van de Sluis
ABSTRACT

Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals. At present, Wilson's disease is the best-described and best-studied copper-storage disorder in humans; it is caused by mutations in the ATP7B gene. In dogs, a mutation in the COMMD1 gene has been found to be associated with copper toxicosis. Using a liver-specific Commd1 knockout mouse, the biological role of Commd1 in copper homeostasis has been confirmed. Yet, the exact mechanism by which COMMD1 regulates copper homeostasis is still unknown. Here, we give an overview of the current knowledge and perspectives on the molecular function of COMMD1 in copper homeostasis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Copper, foil, ≥99.8% (complexometric)
Sigma-Aldrich
Copper, beads, 2-8 mm, ≥99.99% trace metals basis
Continuous cast copper (O), BCR®, certified reference material, rod
Sigma-Aldrich
Copper, foil, thickness 1.0 mm, 99.999% trace metals basis
Sigma-Aldrich
Copper, beads, 2-8 mm, 99.9995% trace metals basis
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Copper, wire, diam. 0.25 mm, 99.999% trace metals basis
Sigma-Aldrich
Copper, powder, <75 μm, 99%
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Copper, foil, thickness 0.025 mm, 99.98% trace metals basis
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Copper, foil, thickness 0.5 mm, 99.98% trace metals basis
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Copper, wire, diam. 1.0 mm, ≥99.9%
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Copper, turnings, purum p.a., ≥99.0%
Sigma-Aldrich
Copper, wire, diam. 0.64 mm, 99.995% trace metals basis
Sigma-Aldrich
Copper, wire, diam. 2.0 mm, 99.999% trace metals basis
Copper - O.F.H.C., foil, light tested, 25x25mm, thickness 0.05mm, hard, 99.95+%
Copper, wire reel, 5m, diameter 1.0mm, as drawn, 99.99+%
Copper - O.F.H.C., foil, 6mm disks, thickness 1.0mm, half hard, 99.95+%
Copper - O.F.H.C., foil, light tested, 150x150mm, thickness 0.05mm, annealed, 99.95+%
Copper - O.F.H.C., rod, 100mm, diameter 25.4mm, as drawn, 99.99+%
Copper - O.F.H.C., rod, 500mm, diameter 16mm, as drawn, 99.95+%
Copper - O.F.H.C., rod, 200mm, diameter 25.4mm, as drawn, 99.95+%
Copper - O.F.H.C., foil, light tested, 150x150mm, thickness 0.05mm, hard, 99.95+%
Copper - O.F.H.C., rod, 200mm, diameter 12.7mm, as drawn, 99.95+%
Copper - O.F.H.C., foil, 8mm disks, thickness 0.1mm, hard, 99.95+%
Copper - O.F.H.C., foil, light tested, 100x100mm, thickness 0.075mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 6mm disks, thickness 0.7mm, half hard, 99.95+%
Copper - O.F.H.C., rod, 1000mm, diameter 3.15mm, as drawn, 99.95+%
Copper - O.F.H.C., foil, light tested, 25x25mm, thickness 0.006mm, hard, 99.95+%
Copper - O.F.H.C., rod, 200mm, diameter 50.0mm, as drawn, 99.95+%
Copper - O.F.H.C., tube, 100mm, outside diameter 0.9mm, inside diameter 0.56mm, wall thickness 0.17mm, 99.95+%
Copper - O.F.H.C., sheet, 300x300mm, thickness 3.0mm, 99.95+%