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  • Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Annals of the New York Academy of Sciences (2014-04-05)
Alina Fedoseienko, Paulina Bartuzi, Bart van de Sluis
ABSTRACT

Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals. At present, Wilson's disease is the best-described and best-studied copper-storage disorder in humans; it is caused by mutations in the ATP7B gene. In dogs, a mutation in the COMMD1 gene has been found to be associated with copper toxicosis. Using a liver-specific Commd1 knockout mouse, the biological role of Commd1 in copper homeostasis has been confirmed. Yet, the exact mechanism by which COMMD1 regulates copper homeostasis is still unknown. Here, we give an overview of the current knowledge and perspectives on the molecular function of COMMD1 in copper homeostasis.

MATERIALS
Product Number
Brand
Product Description

Copper, wire reel, 0.2m, diameter 1.0mm, as drawn, 99.99+%
Copper - O.F.H.C., foil, 10mm disks, thickness 0.25mm, annealed, 99.95+%
Copper - O.F.H.C., foil, 20m coil, thickness 0.010mm, coil width 25mm, hard, 99.95+%
Copper - O.F.H.C., foil, 10m coil, thickness 0.1mm, hard, 99.95+%
Copper, tube, 500mm, outside diameter 1.0mm, inside diameter 0.24mm, wall thickness 0.38mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.075mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 2m coil, thickness 0.025mm, hard, 99.95+%
Copper - O.F.H.C., foil, 300x300mm, thickness, 0.5mm, half hard, flattened, 99.95+%
Copper - O.F.H.C., foil, 10mm disks, thickness 0.075mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 20m coil, thickness 0.05mm, coil width 10mm, annealed, 99.95+%
Copper - O.F.H.C., foil, 15mm disks, thickness 0.125mm, hard, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.010mm, hard, 99.95+%
Copper - O.F.H.C., foil, 4mm disks, thickness 0.010mm, hard, 99.95+%
Copper - O.F.H.C., foil, 15mm disks, thickness 1.0mm, half hard, 99.95+%
Copper, tube, 500mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 10mm disks, thickness 0.1mm, hard, 99.95+%
Copper - O.F.H.C., foil, 10m coil, thickness 0.05mm, hard, 99.95+%
Copper - O.F.H.C., foil, 10mm disks, thickness 1.0mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 2m coil, thickness 0.20mm, hard, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.1mm, half hard, 99.95+%
Copper, tube, 500mm, outside diameter 2.5mm, inside diameter 1.9mm, wall thickness 0.3mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 15mm disks, thickness 0.25mm, annealed, 99.95+%
Copper - O.F.H.C., foil, 10mm disks, thickness 0.05mm, hard, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.05mm, coil width 10mm, annealed, 99.95+%
Copper - O.F.H.C., foil, 25mm disks, thickness 0.025mm, hard, 99.95+%
Copper - O.F.H.C., foil, 4mm disks, thickness 0.025mm, hard, 99.95+%
Copper, wire reel, 100m, diameter 0.025mm, as drawn, 99.99+%
Copper - O.F.H.C., foil, 5m coil, thickness 0.05mm, coil width 300mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 10m coil, thickness 0.125mm, hard, 99.95+%
Copper, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.999%