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The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86.

The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86.

Future medicinal chemistry (2011-04-30)

Oluwatayo F Ikotun, Suzanne E Lapi

ABSTRACT

Positron emission tomography, with its high sensitivity and resolution, is growing rapidly as an imaging technology for the diagnosis of many disease states. The success of this modality is reliant on instrumentation and the development of effective and novel targeted probes. Initially, research in this area was focused on what we will define in this article as 'standard' PET isotopes (carbon-11, nitrogen-13, oxygen-15 and fluorine-18), but the short half-lives of these isotopes limit radiopharmaceutical development to those that probe rapid biological processes. To overcome these limitations, there has been a rise in nonstandard isotope probe development in recent years. This review focuses on the biological probes and processes that have been examined, in additiom to the preclinical and clinical findings with nonstandard radiometals: copper-64, zirconium-89, and yttrium-86.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Zirconium, powder, −100 mesh

Sigma-Aldrich

Zirconium, foil, thickness 0.1 mm, 99.98% trace metals basis

Sigma-Aldrich

Zirconium, sponge, ≥99% trace metals basis

Sigma-Aldrich

Zirconium, rod, diam. 6.35 mm, ≥99% trace metals basis

Zirconium, foil, not light tested, 25x25mm, thickness 0.003mm, 99.2%

Zirconium, foil, light tested, 50x50mm, thickness 0.015mm, 99.2%

Zirconium, foil, light tested, 25x25mm, thickness 0.006mm, 99.2%

Zirconium, foil, 8mm disks, thickness 0.25mm, annealed, 99.2%

Zirconium, foil, 8mm disks, thickness 0.5mm, annealed, 99.2%

Zirconium, foil, 6mm disks, thickness 0.075mm, annealed, 99.2%

Zirconium, foil, light tested, 25x25mm, thickness 0.01mm, 99.2%

Zirconium, foil, 4mm disks, thickness 0.01mm, 99.2%

Zirconium, foil, 4mm disks, thickness 0.25mm, annealed, 99.2%

Zirconium, foil, 6mm disks, thickness 0.25mm, annealed, 99.2%

Zirconium, foil, light tested, 50x50mm, thickness 0.05mm, annealed, 99.2%

Zirconium, foil, 50mm disks, thickness 0.25mm, annealed, 99.2%

Zirconium, foil, light tested, 25x25mm, thickness 0.01mm, 99.2%

Zirconium, foil, 6mm disks, thickness 0.01mm, 99.2%

Zirconium, foil, 50mm disks, thickness 0.016mm, 99.2%

Zirconium, foil, light tested, 50x50mm, thickness 0.008mm, 99.2%

Zirconium, foil, not light tested, 25x25mm, thickness 0.005mm, 99.2%

Zirconium, foil, light tested, 50x50mm, thickness 0.01mm, 99.2%

Zirconium, foil, light tested, 200x300mm, thickness 0.02mm, 99.2%

Zirconium, foil, 4mm disks, thickness 0.075mm, annealed, 99.2%

Zirconium, foil, 6mm disks, thickness 0.009mm, 99.2%

Zirconium, foil, 25mm disks, thickness 0.125mm, annealed, 99.2%

Zirconium, foil, 2m coil, thickness 0.075mm, annealed, 99.2%

Zirconium, foil, 5m coil, thickness 0.025mm, annealed, 99.2%

Zirconium, foil, light tested, 100x100mm, thickness 0.01mm, 99.2%

Zirconium, foil, light tested, 100x100mm, thickness 0.016mm, 99.2%