- A new antitumour ansamitocin from Actinosynnema pretiosum.
A new antitumour ansamitocin from Actinosynnema pretiosum.
Natural product research (2010-06-29)
Guo-Zhu Wei, Lin-Quan Bai, Tao Yang, Juan Ma, Ying Zeng, Yue-Mao Shen, Pei-Ji Zhao
PMID20582809
ABSTRACT
A new compound of ansamitocin was isolated from the extracts of fermentation medium of mutant strain HGF052 derived from Actinosynnema pretiosum ssp. aurantium ATCC 31565, and identified as N-demethyl-desepoxy-9-methoxy-maytansinol (1) on the basis of extensive spectroscopic methods. Bioassay results showed that compound 1 had cytotoxic activity against HL-60 and BEL-7402 cell lines.
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