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Pyrrolidine PNA: a novel conformationally restricted PNA analogue.

Organic letters (2001-01-11)
A Püschl, T Tedeschi, P E Nielsen
PMID11150189
ABSTRACT

[reaction:see text] A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA adenine decamer.

MATERIALS
Product Number
Brand
Product Description
H5877
Sigma-Aldrich
cis-4-Hydroxy-D-proline