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  • Existence of Gαi2-expressing axon terminals in the goat main olfactory bulb.

Existence of Gαi2-expressing axon terminals in the goat main olfactory bulb.

The Journal of veterinary medical science (2012-08-11)
Hiromi Ohara, Hiroaki Okamura, Masumi Ichikawa, Yuji Mori, Kimiko Hagino-Yamagishi
ABSTRACT

In rodents, Gα(i2)-expressing sensory neurons (SNs) that co-express vomeronasal receptor type 1 (V1R) are specifically found in the vomeronasal organ (VNO) and project their axons to the accessory olfactory bulb (AOB). In goats, however, Gα(i2)/V1R-expressing SNs exist in both the VNO and the olfactory epithelium. Thus, we examined whether the Gα(i2)-expressing axons functionally project to the main olfactory bulb (MOB). We analyzed the expression of Gα(i2) in the olfactory bulb and found small Gα(i2)-immunoreactive clusters in the MOB. The Gα(i2)-immunoreactive axons in these clusters made synaptic contacts with second-order neurons in the MOB. These results suggest that some Gα(i2)-expressing SNs functionally project their axons to the MOB in goats.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-G Protein Giα-2 Antibody, clone L5, clone L5, Chemicon®, from mouse