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1370270

USP

Loratadine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine

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About This Item

Empirical Formula (Hill Notation):
C22H23N2O2Cl
CAS Number:
79794-75-5
Molecular Weight:
382.88
MDL number:
MFCD00672869
UNSPSC Code:
41116107
PubChem Substance ID:
329750256
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

loratadine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Loratadine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Loratadine Capsules
  • Loratadine Chewable Tablets
  • Loratadine Oral Solution
  • Loratadine Orally Disintegrating Tablets
  • Loratadine Tablets

Biochem/physiol Actions

Non-sedating histamine H1-receptor antagonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Product No.
Description
Pricing

1370280

Loratadine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1370291

Loratadine Related Compound B, United States Pharmacopeia (USP) Reference Standard

Y0000603

Loratadine for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0000688

Loratadine, European Pharmacopoeia (EP) Reference Standard

Y0000604

Loratadine impurity F, European Pharmacopoeia (EP) Reference Standard

Y0000605

Loratadine impurity H, European Pharmacopoeia (EP) Reference Standard

1370269

Loratadine Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP874

Loratadine, British Pharmacopoeia (BP) Reference Standard

BP875

Loratadine impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR2308

Loratadine Related Compound B

PHR2309

Loratadine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Standard

PHR2313

Loratadine Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2310

Loratadine Impurity A, certified reference material, pharmaceutical secondary standard

PHR2311

Loratadine Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Haria et al.
Drugs, 48(4), 617-637 (1994-10-01)
Loratadine is a long-acting antihistamine agent, exhibiting partial selectivity for peripheral histamine H1-receptors. To date, loratadine has been evaluated in allergic rhinitis, urticaria and, to a limited extent, in asthma. In several large controlled comparative clinical studies, loratadine was superior
I J Roman et al.
Clinical reviews in allergy, 11(1), 89-110 (1993-01-01)
Antihistamines are considered first-line therapy for the relief of symptoms from allergic rhinitis and chronic urticaria. The newer, second-generation, nonsedating antihistamines reduce the central nervous system and anticholinergic side effects commonly found with previous drugs. The availability of H1-receptor antagonists
M R Namazi
Journal of the European Academy of Dermatology and Venereology : JEADV, 19(3), 319-322 (2005-04-29)
As the current antipsoriatic medications are commonly associated with deleterious side-effects, a determined search for safer agents, which could be used alone or in combination with current antipsoriatic drugs, would be very imperative. Psoriasis is believed to be characterized by
G Ciprandi et al.
Journal of investigational allergology & clinical immunology, 1(6), 368-372 (1991-12-01)
This double-blind, double-dummy, parallel-group study was undertaken in 40 patients with seasonal allergic rhinoconjunctivitis during the 1990 hay fever season. The patients were randomized and treated for seven days with either 120 mg terfenadine or 10 mg loratadine, each drug
Eleanor B Schwarz et al.
Drug safety, 31(9), 775-788 (2008-08-19)
Loratadine, a second-generation antihistamine, is commonly used to treat seasonal allergies. Some studies have suggested that use of loratadine by pregnant women increases the risk of hypospadias in male offspring. This meta-analysis was designed to assess the strength of the
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