SML1828

EMD-87580

≥98% (HPLC)

• Synonym(s): EMD87580, N-[2-methyl-4,5-bis(methylsulfonyl)-benzoyl]-guanidine
• Empirical Formula (Hill Notation): C₁₁H₁₅N₃O₅S₂
• CAS Number: 187870-78-6
• Molecular Weight: 333.38
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: NC(NC(C1=CC(S(=O)(C)=O)=C(S(=O)(C)=O)C=C1C)=O)=N
• InChI: 1S/C11H15N3O5S2/c1-6-4-8(20(2,16)17)9(21(3,18)19)5-7(6)10(15)14-11(12)13/h4-5H,1-3H3,(H4,12,13,14,15)
• InChI key: GROMEQPXDKRRIE-UHFFFAOYSA-N

Description

Application

EMD-87580 has been used as a selective and potent sodium-hydrogen antiporter 1 (NHE-1) inhibitor in cardiac ventricular myocytes to test its effect on the hypertrophic response.

Biochem/physiol Actions

EMD-87580 is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. EMD-87580 has shown cardioprotective effects, and has been investigated as a possible treatment for Duchenne′s muscular dystrophy.

Inhibitor of sodium-hydrogen exchanger-1 (NHE-1)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable