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P7794

Penicillin G potassium salt

powder, suitable for cell culture, BioReagent

Penicillin G potassium salt

Synonym(s):

Benzylpenicillin potassium salt

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About This Item

Empirical Formula (Hill Notation):
C16H17KN2O4S
CAS Number:
Molecular Weight:
372.48
PubChem Substance ID:
eCl@ss:
34010400
UNSPSC Code:
12352207
NACRES:
NA.76
EC Number:
204-038-0
MDL number:
Beilstein/REAXYS Number:
3832841
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Product Name

Penicillin G potassium salt, powder, BioReagent, suitable for cell culture

product line

BioReagent

Quality Level

form

powder

potency

1440-1680 units per mg

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell wall synthesis | interferes

SMILES string

[K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

InChI

1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChI key

IYNDLOXRXUOGIU-LQDWTQKMSA-M

General description

Chemical structure: β-lactam

Application

Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Disclaimer

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The potassium salt is soluble in H2O at 100 mg/mL.

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This Item
P87211502508PENK
mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

-

mode of action

cell wall synthesis | interferes

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

product line

BioReagent

product line

-

product line

-

product line

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

200

form

powder

form

crystalline powder

form

powder

form

powder


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pictograms

Exclamation mark

signalword

Warning

hcodes

pcodes

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



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R Comunian et al.
Journal of dairy science, 93(12), 5644-5650 (2010-11-26)
Antibiotics are widely used for therapeutic and prophylactic purposes in dairy animals. The presence of residual antibiotics in milk could cause potentially serious problems in human health and have technological implication in the manufacturing of dairy products. The aim of
Lavinia Florina Călinoiu et al.
Biomolecules, 10(1) (2019-12-28)
The aim of the present paper was to identify the major polyphenolic compounds and investigate the antioxidant, antimutagenic, and antimicrobial activities of industrially-derived cereal byproducts-wheat bran (WB) and oat bran (OB)-before (fresh) and after thermal processing (TP) (10 min, 80
Yulei Zhao et al.
American journal of translational research, 13(6), 7077-7082 (2021-07-27)
To explore the CD200/CD200R expression level in the peripheral blood mononuclear cells (PBMC) of hematological malignancy patients and to analyze its mechanism of action. Thirty hematological malignancy patients who were hospitalized in our hospital from June 2019 to December 2019



Global Trade Item Number

SKUGTIN
P7794-1MU04061835569267
P7794-10MU04061835569250
P7794-100MU04061835569243

Questions

1–2 of 2 Questions  
  1. ¿A qué temperatura debe de almacenarse este producto en polvo y por cuánto tiempo es estable?

    1 answer
    1. This product may be stored in room temperature. Concerning expiration, this product is assigned a product retest date. Products that, while considered stable, may be subject to degradation over time are assigned a periodic retest date to confirm quality. The lot specific retest date is reported on the Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
      https://www.sigmaaldrich.com/product/sigma/p7794#product-documentation

      Helpful?

  2. Is the reported potency for P7794 Penicillin G potassium salt based on the anhydrous/dried form, or is it based on an as-it-is basis? Also, what does the "S" signify in U/mgS for the reported potency results?

    1 answer
    1. The potency test is reported on an "as is" basis. The "S" in U/mgS stands for unit per milligram solid.

      Helpful?

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