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A1263

Sigma-Aldrich

DL-Amphetamine sulfate salt

Synonym(s):

(±)-α-Methylphenethylamine sulfate salt

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About This Item

Linear Formula:
C18H26N2 · H2SO4
CAS Number:
60-13-9
Molecular Weight:
368.49
EC Number:
200-457-8
MDL number:
MFCD00070254
UNSPSC Code:
12352116
PubChem Substance ID:
329770696
NACRES:
NA.77

form

powder

Quality Level

100

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

application(s)

forensics and toxicology

SMILES string

OS(O)(=O)=O.CC(N)Cc1ccccc1.CC(N)Cc2ccccc2

InChI

1S/2C9H13N.H2O4S/c2*1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2*2-6,8H,7,10H2,1H3;(H2,1,2,3,4)

InChI key

PYHRZPFZZDCOPH-UHFFFAOYSA-N

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Application

DL-Amphetamine sulfate salt has been used to induce place preference in rats to study the effect of diazepam and zolpidem. It has also been used as a drug standard in the digital image-based colorimetric presumptive test.

Biochem/physiol Actions

DL -Amphetamine, also known as benzedrine, is a synthetic stimulant. It is usually produced as a sulfate salt (DL-amphetamine sulfate salt). DL-Amphetamine sulfate may be used to treat children with behavior disorders., Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 3 - Repr. 2 - STOT RE 2 - STOT SE 3

Target Organs

Brain, Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Madeleine P Strohl
The Yale journal of biology and medicine, 84(1), 27-33 (2011-04-01)
In 1937, psychiatrist Charles Bradley administered Benzedrine sulfate, an amphetamine, to "problem" children at the Emma Pendleton Bradley Home in Providence, Rhode Island, in an attempt to alleviate headaches; however, Bradley noticed an unexpected effect upon the behavior of the
E Meririnne et al.
Pharmacology, biochemistry, and behavior, 62(1), 159-164 (1999-02-11)
Drugs such as benzodiazepines, which enhance the effects of inhibitory neurotransmitter gamma-amino butyric acid (GABA), are known to modulate the mesocorticolimbic dopaminergic system, which is considered to mediate the rewarding effects of psychostimulants. The effects of diazepam, a benzodiazepine that
Aree Choodum et al.
Drug testing and analysis, 3(5), 277-282 (2011-03-10)
Digital image analysis was applied to the products of simple colorimetric [corrected] tests for amphetamine and methylamphetamine. Adobe Photoshop software was used for colour analysis to obtain analytical data in the form of a Red Green Blue (RGB) value. Calibration
Maria Xilouri et al.
Brain : a journal of neurology, 136(Pt 7), 2130-2146 (2013-06-13)
α-Synuclein levels are critical to Parkinson's disease pathogenesis. Wild-type α-synuclein is degraded partly by chaperone-mediated autophagy, and aberrant α-synuclein may act as an inhibitor of the pathway. To address whether the induction of chaperone-mediated autophagy may represent a potential therapy
Rita Perfeito et al.
Free radical biology & medicine, 62, 186-201 (2013-06-08)
Parkinson disease (PD) is a chronic and progressive neurological disease associated with a loss of dopaminergic neurons. In most cases the disease is sporadic but genetically inherited cases also exist. One of the major pathological features of PD is the
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