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A0752

Sigma-Aldrich

Adenosine 5′-diphosphoribose sodium salt

≥93%

Synonym(s):

ADPR, ADP-Ribose

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About This Item

Empirical Formula (Hill Notation):
C15H23N5O14P2
CAS Number:
68414-18-6
Molecular Weight:
559.32
MDL number:
MFCD00136017
UNSPSC Code:
41106305
PubChem Substance ID:
24890449
NACRES:
NA.51

biological source

yeast (candida utilis)

Assay

≥93%

form

powder

storage temp.

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O

InChI

1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;

InChI key

NWPVXDZLQTURKI-UHFFFAOYSA-N

Related Categories

Application

5′-Deoxy-5′-(methylthio)adenosine has been used:
  • to give a range of nicotinamide adenine dinucleotide (NADH)
  • oxidation rates for the respiratory complex (CI/CIII/CIV)
  • CI/alternative(AOX) pathway
  • to measure poly(ADP-ribose) glycohydrolaseactivity
  • poly(ADP-ribose) (PAR) binding competition assay
  • oxidase (AOX) pathway
  • to measure poly(ADP-ribose) glycohydrolase activity
  • poly(ADP-ribose) (PAR) binding competition assay

Biochem/physiol Actions

Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling. ADP-Ribose initiates the transient receptor potential subfamily melastatin, type2 (TRPM2), a Na+, Ca2+, and K+ cation channel.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Journal of cellular biochemistry, 117(5), 1136-1144 (2015-10-09)
Combination chemotherapy is an effective strategy for increasing anticancer efficacy, reducing side effects and alleviating drug resistance. Here we report that combination of the recently identified novel chalcone derivative, chalcone-24 (Chal-24), and TNF-related apoptosis-inducing ligand (TRAIL) significantly increases cytotoxicity in
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