MABF216

Anti-Microsialin/CD68 Antibody, clone 9

clone 9, 1 mg/mL, from rat

• Synonym(s): Macrosialin, CD68
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rat
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 9, monoclonal
• species reactivity: mouse
• concentration: 1 mg/mL
• technique(s): flow cytometry: suitable
• isotype: IgG2aκ
• NCBI accession no.: NP_033983
• UniProt accession no.: P31996
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: mouse ... Cd68(12514)

Description

General description

Microsialin/CD68, also known as Macrosialin, Gp110, CD_antigen 68, or CD68, and encoded by the gene CD68, is a membrane protein expressed in macrophages (and other cells) that appears to play a role in the phagocytic activities of tissue macrophages both in intracellular lysosomal metabolism but also in extracellular cell to cell interactions and cell pathogen interactions. Microsialin binds to tissue and organ-specific lectins or selectins mediating homing of macrophage subsets to particular sites. Also, rapid recirculation of Microsialin from the endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selection-bearing substrates or other cells. Microsialin is expressed in blood monocytes and tissue macrophages primarily but is also found expressed in lymphocytes, fibroblasts and endothelial cells so it is not an exclusive marker for macrophages. Also Microsialin is expressed on many tumor cells which seem to allow the tumor cells to attach to selectins on the vascular endothelium facilitating their dissemination to secondary sites.

Immunogen

Recombinant protein corresponding to mouse Microsialin/CD68.

Application

Anti-Microsialin/CD68 Antibody, clone 9 is an antibody against Microsialin/CD68 for use in flow cytometry.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Physical form

Format: Purified

Protein G Purified

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable