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Sigma-Aldrich

Anti-53BP1 Antibody, clone BP13

clone BP13, Upstate®, from mouse

Synonym(s):

Anti-53BP1, Anti-p202, Anti-p53BP1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

BP13, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... TP53BP1(7158)

Specificity

53BP1

Immunogen

Mix of three GST fusion proteins corresponding to residues 1-337, 338-671, and 1331-1664, respectively, of human 53BP1

Application

Detect 53BP1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.
Does not cross-react with mouse.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Quality

routinely evaluated by immunoblot on lysates from HeLa cells

Target description

~250kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Purified

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile.
Fay Minty, Johanna K Thurlow, Paul R Harrison, E Kenneth Parkinson
Experimental Cell Research null
Guanghua Du et al.
Radiation research, 176(6), 706-715 (2011-07-30)
High-linear energy transfer (LET) ion irradiation of cell nuclei induces complex and severe DNA lesions, and foci of repair proteins are formed densely along the ion trajectory. To efficiently discriminate the densely distributed/overlapping foci along the ion trajectory, a focus
Quantitative analysis of DNA-damage response factors after sequential ion microirradiation.
Christoph Greubel, Volker Hable, Guido A Drexler, Andreas Hauptner, Steffen Dietzel et al.
Radiation and Environmental Biophysics null
I M Ward et al.
The Journal of biological chemistry, 276(51), 47759-47762 (2001-10-24)
H2AX, a member of the histone H2A family, is rapidly phosphorylated in response to ionizing radiation. This phosphorylation, at an evolutionary conserved C-terminal phosphatidylinositol 3-OH-kinase-related kinase (PI3KK) motif, is thought to be critical for recognition and repair of DNA double
I Rappold et al.
The Journal of cell biology, 153(3), 613-620 (2001-05-02)
The tumor suppressor p53 binding protein 1 (53BP1) binds to the DNA-binding domain of p53 and enhances p53-mediated transcriptional activation. 53BP1 contains two breast cancer susceptibility gene 1 COOH terminus (BRCT) motifs, which are present in several proteins involved in

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