Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.

Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality.

Cell death & disease (2017-05-26)

Ge Li, Chentong Xu, Xin Lin, Liujing Qu, Dan Xia, Beiqi Hongdu, Yan Xia, Xiaokun Wang, Yaxin Lou, Qihua He, Dalong Ma, Yingyu Chen

PMID28542142

RESUMEN

Programmed cell death 5 (PDCD5) is an apoptosis promoter molecule that displays multiple biological activities. However, the function of PDCD5 in vivo has not yet been investigated. Here, we generated a Pdcd5 knockout mouse model to study the physiological role of PDCD5 in vivo. Knockout of the Pdcd5 gene resulted in embryonic lethality at mid-gestation. Histopathological analysis revealed dysplasia in both the LZs and JZs in Pdcd5