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Blood vessel anastomosis is spatially regulated by Flt1 during angiogenesis.

Development (Cambridge, England) (2017-03-02)
Jessica E Nesmith, John C Chappell, Julia G Cluceru, Victoria L Bautch
RESUMEN

Blood vessel formation is essential for vertebrate development and is primarily achieved by angiogenesis - endothelial cell sprouting from pre-existing vessels. Vessel networks expand when sprouts form new connections, a process whose regulation is poorly understood. Here, we show that vessel anastomosis is spatially regulated by Flt1 (VEGFR1), a VEGFA receptor that acts as a decoy receptor.

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Triton X-100, laboratory grade
Sigma-Aldrich
MISSION® esiRNA, targeting human AR
Sigma-Aldrich
MISSION® esiRNA, targeting human FLT1