- Effect of benzyl nicotinate on the percutaneous absorption of dexamethasone in the rat.
Effect of benzyl nicotinate on the percutaneous absorption of dexamethasone in the rat.
European journal of drug metabolism and pharmacokinetics (1980-01-01)
M A Kassem, K E Schulte
PMID7389748
RESUMEN
The effect of benzyl nicotinate (15 mg) on the percutaneous absorption of dexamethasone 0,1 mg (62,5 uCi)/6 cm2, in an ethanol/octanol vehicle has been investigated in the rat. Both the urinary excretion and blood concentration data showed that benzyl nicotinate had a pronounced stimulating effect on the rate and extent of absorption. The relative bioavailability of dexamethasone was found to be 120% (urinary excretion data) or 146% (blood concentration data). Peak blood concentration increased greatly and was reached more quickly (1 1/2 hours instead of 2 1/2 hours).
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