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Palladium-catalyzed carbonylation reaction of aryl bromides with 2-hydroxyacetophenones to form flavones.

Chemistry (Weinheim an der Bergstrasse, Germany) (2012-08-29)
Xiao-Feng Wu, Helfried Neumann, Matthias Beller
RESUMEN

Flavone of the month: a general and efficient method for the palladium-catalyzed carbonylative synthesis of flavones has been developed. Starting from aryl bromides and 2-hydroxyacetophenones, the corresponding flavones have been isolated in good yields.

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Sigma-Aldrich
2′-Hydroxyacetophenone, ReagentPlus®, 99%
Sigma-Aldrich
2′-Hydroxyacetophenone, ≥98%