A glutaric acid ester as carrier system for sustained delivery of lamuvidine (3TC) dimers.

A glutaric acid ester as carrier system for sustained delivery of lamuvidine (3TC) dimers.

Nucleosides, nucleotides & nucleic acids (2007-12-07)

H B Lazrek, J J Vasseur, Jack Secrist, Joachim W Engels

RESUMEN

We report the synthesis of homo and heterodimers of 3TC conjugates. All new dimers were screened for their ability to inhibit HIV-1 in MT4 cell line and were compared to AZT alone and showed marked antiviral activity.

MATERIALES

Referencia del producto

Marca

Descripción del producto

G3806

Sigma-Aldrich

Glutaric anhydride, 95%