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Merck

Study on glycosylated prodrugs of toxoflavins for antibody-directed enzyme tumor therapy.

Carbohydrate research (2007-04-07)
Shusheng Wang, Dan Liu, Xu Zhang, Shengyu Li, Yongxu Sun, Jia Li, Yifa Zhou, Liping Zhang
RESUMEN

Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by (13)C NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against beta-glucosidase (EC.3.2.1.21).

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Sigma-Aldrich
PKF118-310, ≥98% (HPLC)