- A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes.
A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes.
Organic & biomolecular chemistry (2006-12-14)
An-Hu Li, Eilaf Ahmed, Xin Chen, Matthew Cox, Andrew P Crew, Han-Qing Dong, Meizhong Jin, Lifu Ma, Bijoy Panicker, Kam W Siu, Arno G Steinig, Kathryn M Stolz, Paula A R Tavares, Brian Volk, Qinghua Weng, Doug Werner, Mark J Mulvihill
PMID17164907
RESUMEN
A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).
MATERIALES