- Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
The Biochemical journal (2002-12-12)
Philippe Soubeyran, Ana Barac, Iwona Szymkiewicz, Ivan Dikic
PMID12475393
RESUMEN
The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.
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ANTI-FLAG® M2 monoclonal antibody produced in mouse, clone M2, purified immunoglobulin (Purified IgG1 subclass), buffered aqueous solution (10 mM sodium phosphate, 150 mM NaCl, pH 7.4, containing 0.02% sodium azide)
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