- Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
Bioorganic & medicinal chemistry letters (2005-09-17)
George P Lahm, Thomas P Selby, John H Freudenberger, Thomas M Stevenson, Brian J Myers, Gilles Seburyamo, Ben K Smith, Lindsey Flexner, Christopher E Clark, Daniel Cordova
PMID16165355
RESUMEN
A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.