- Discovery of a beta-MSH-derived MC-4R selective agonist.
Discovery of a beta-MSH-derived MC-4R selective agonist.
Journal of medicinal chemistry (2005-04-29)
John P Mayer, Hansen M Hsiung, David B Flora, Patrick Edwards, Dennis P Smith, Xing-Yue Zhang, Robert A Gadski, Mark L Heiman, Jeanne L Hertel, Paul J Emmerson, Saba Husain, Thomas P O'brien, Steven D Kahl, David L Smiley, Lianshan Zhang, Richard D Dimarchi, Liang Zeng Yan
PMID15857110
RESUMEN
A series of novel, disulfide-constrained human beta-melanocyte stimulating hormone (beta-MSH)-derived peptides were optimized for in vitro melanocortin-4 receptor (MC-4R) binding affinity, agonist efficacy, and selectivity. The most promising of these, analogue 18, was further studied in vivo using chronic rat food intake and body weight models.
MATERIALES
Referencia del producto
Marca
Descripción del producto